• Alternative names
• Defination
• Causes, Incidence and Risk Factors

• Prevention
• Symptoms
• Signs & Tests
• Treatment

• Expectations
• Complications
• Calling Your health care provider

Definition

Macular degeneration is the physical disturbance of the center of the retina called the macula. The macula, which is about the size of the capital letter "O" in this sentence, is the part of the retina which is capable of our most acute and detailed vision. We use the macula for reading, driving, recognizing faces, watching television, and fine work. Macular degeneration is the leading cause of legal blindness in people over age 55. (Legal blindness means that a person can see 20/200 or less with eyeglasses.) Even with a loss of central vision, however, color vision and peripheral vision may remain clear. Vision loss usually occurs gradually and typically affects both eyes at different rates.

Causes, Incidence and Risk Factors

The root causes of macular degeneration are still unknown. There are two forms of age-related macular degeneration, "wet" and "dry". Seventy percent of patients have the "dry" form, which involves thinning of the macular tissues and disturbances in its pigmentation. Thirty percent have the "wet" form, which can involve bleeding within and beneath the retina, opaque deposits, and eventually scar tissue. The "wet" form accounts for ninety percent of all cases of legal blindness in macular degeneration patients.

Different forms of macular degeneration may occur in younger patients. These non-age related cases may be linked to heredity, diabetes, nutritional deficits, head injury, infection, or other factors. The Schepens scientists are undertaking the basic research necessary to determine the causes of these disorders. Finding the cause is the first important step toward prevention and cure.

Prevention

• Have annual routine eye exams
• See your ophthalmologist without delay if you notice any decline in your vision Volunteer to participate in eye studies.
• Volunteers with all levels of vision are sought by researchers. The Schepens is currently recruiting volunteers aged 40-50 to participate for studies on macular degeneration.
• Make whatever financial contributions you can to support eye research at centers like The Schepens.

Symptoms

Declining vision noticed by the patient or by an ophthalmologist during a routine eye exam may be the first indicator of macular degeneration. The formation of new blood vessels and exudates, or "drusen," from blood vessels in and under the macular is often the first physical sign that macular degeneration may develop. In addition, the following signs may be indicative of macular problems. Anyone experiencing these symptoms should consult an ophthalmologist immediately:

• Straight lines appear distorted and, in some cases, the center of vision appears more distorted than the rest of the scene.
• A dark, blurry area or "white-out" appears in the center of vision.
• Color perception changes or diminishes.

The following are NOT known to be linked to macular degeneration: floaters (moving spots caused by debris floating in the vitreous fluid between the lens and the retina); dry eye syndromes; cataracts and cataract surgery.

Is early detection important?

Early detection is important because a patient destined to develop macular degeneration can sometimes be treated before symptoms appear, and this may delay or reduce the severity of the disease. Furthermore, as we develop better treatments for macular degeneration, whether they are medicinal, surgical, or low vision aids, those patients diagnosed with macular degeneration can sooner benefit from them.

Treatment

At this time there is no known cure for macular degeneration. In some cases, macular degeneration may be active and then slow down considerably, or even stop progressing for many, many years. One day, research may show us how to prevent and reverse the disease. Today, there are ways to arrest macular degeneration, depending on the type and the degree of the condition. These range from nutritional intervention to laser surgery of the blood vessels (see below). We also have developed low vision aids and techniques for maximizing the use of peripheral vision to help patients adapt better to their loss of central vision. Educating susceptible groups about macular degeneration can enhance early detection and early treatment. We advise that a patient select and eye center that specializes in macular degeneration and get opinions for treatment from retina specialists.

Surgery to remove the scar produced by macular degeneration has been successful in younger patients, but less successful in older patients. If the degeneration is associated with leaking blood vessels in the center of the macula, and vision is worse than 20/70, laser surgery, called photocoagulation, is recommended. This will not improve vision but generally reduces further vision loss. Retinal transplantation is a new experimental approach to macular degeneration, but will require at least 3 - 5 years of clinical research at The Schepens and other centers to determine its safety and effectiveness.

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